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An A to G transition mutation was introduced at nucleotide residue 118 in exon 1 converting a lysine into an arginine (K14R). This mutation increased the half-life of the protein from about 22 minutes to about 30 minutes without knocking out repressor activity. In situ analysis indicates that the mutant protein is expressed. (J:91127)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
