Log In|Sign Up
EN
A point mutation was introduced into exon 7, resulting in a valine to serine substitution at residue 290 (V290S). Exon 7 encodes the M2 channel domain. Cre-mediated recombination removed a floxed neo that was inserted into intron 5. PCR confirmed recombination and RT-PCR indicated reduced levels of mRNA in mutants. (J:90942)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
