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This allele has a deletion of approximately 4.6 kb in the Imu-Cmu intron. Cre-mediated recombination removed a floxed neo inserted in the intron, leaving a loxp sequence. Homozygous mutants displayed a 5- to 20-fold decrease in surface expression of IgG1, IgG3 and IgA, and a 2- to 5- fold decrease in IgG2b and IgG2a as compared to wild-type. No alteration was found in IgM expression. (J:90548)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
