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Exon 1, which encodes most of the protein and the entire CRD, was replaced by a LacZ/MC1-neo cassette. PCR analysis demonstrated that homozygous mutants contained the LacZ gene. Northern blot of kidneys indicated no presence of transcript for the CRD domain of the endogenous gene. RT-PCR analysis of calvaria showed lack of expression of both the CRD (the 5' region of the transcript) and the netrin domain (the 3' region) in mutants. (J:89547)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
