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CTCF target site 4 within the imprinting control region (ICR) was modified from a central GTGG motif to ATAT via homologous recombination. A floxed neomycin resistance gene cassette that was included in the targeting vector was excised via in vivo cre-mediated recombination in the germ line. Southern blot analysis and sequence analysis confirmed recombination. (J:89915)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
