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Cre-mediated recombination removed the floxed neo in Kittm3Bsm, leaving a single loxP site in intron 9 and the tyrosine 567 to phenylalanine mutation. Flow cytometry indicated that receptor levels were reduced to 50-60% of normal levels, and Rnase protection assay showed that transcripts are reduced to 50-60% of normal levels, putatively indicating that the remaining lox site and flanking sequences in intron 9 of the mutant affects RNA transcription and/or splicing. (J:90485)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
