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The transgene expresses the cDNA encoding firefly luciferase under control of the heat shock protein 1B (Hsp1b) promoter. This promoter contains four tandem heat shock elements, each recognized by a specific heat shock factor; an inverted CCAAT box; a TATA box; two Sp1 binding sites; and an AP2 binding site. The transgene's expression mirrors that of the endogenous Hsp1b gene during preimplantation embryonic development: both are expressed constitutively at high levels at the 2-cell stage and are inducible from the blastocyst stage forward. (J:22556)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
