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A point mutation was introduced into exon 17 causing a valine to isoleucine change at amino acid residue 642 (V642I) together with a floxed neomycin resistance gene in intron 17. The neomycin gene was subsequently excised from correctly targeted clones by transient cre expression. The mutation was confirmed in mice by genomic DNA sequencing. (J:90296, J:90561)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
