Single loxP sites flanked a genomic region encompassing exons 2 through 6. The floxed region encodes the extracellular domain, the transmembrane domain, and most of the intracellular domain. The floxed region also contains a single frt site, a remnant from the excision of an frt-flanked neo cassette used for selection. (J:89758)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count