An engineered promoter region was derived from the Bglap2 proximal region, consisting of 6 copies of two osteoblast-specific cis-acting elements, OSE2 and OSE1. This promoter region was adjoined to sequence encoding cre recombinase, which was expressed in both bone and cartilage tissue. (J:77071)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count