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Floxed exon 2 and neo cassette are removed following transient Cre-mediated recombination, leaving a single loxP site. Removal of exon 2 putatively generates a null mutation by preventing the encoding of F box as well as the creation of a frameshift mutation and a premature stop codon after encoding 5 amino acids and 39 amino acids, respectively. PCR confirmed recombination. (J:89060)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
