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The majority of exon 3 was replaced with a tau-lacZ reporter and a floxed PGK-neo cassette. A point mutation was introduced into the initiator ATG to create a stop codon. X-gal staining showed beta-galactosidase activity was present in mutant brains. Endogenous mRNA was absent as shown by Northern blot, and a two-site immunoassay confirmed that no peptides were detected in mutant plasma. (J:89244)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
