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Cre-mediated recombination removed floxed exons 12 and 14 of L1camtm1Vlem, leaving a neo cassette in intron 14. These exons encode the sixth Ig domain. Protein expression levels were similar in mutant and wild-type lymphocytes, as demonstrated by Western blot, and flow cytometry confirmed the loss of expression of the sixth Ig domain epitope. (J:89300)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
