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The loxP site flanked STOP cassette was removed from Trp53tm3Tyj via Cre-mediated recombination, allowing for the expression of the p.R270H missense mutation in exon 8. Quantitative RT-PCR confirmed that the point mutation allele was expressed at a level comparable to wild-type. (J:126915)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
