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To define the requirements of the prion protein for conferring susceptibility to scrapie, deletion mutants of the mouse Prnp gene were constructed and used to generate transgenic mice on a background homozygous for a targeted mutation of the endogenous Prnp gene. In this transgenic line, the sequence encoding two of the five copies of the octa repeat (amino acids 68-83) was deleted, in addition to the larger of the two introns. (J:32214)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
