Homologous recombination results in the deletion of a 15 kb region from exon 3 of the Il13 locus to intron 3 of the Il4 locus. RT-PCR and ELISAs failed to detect any Il4 or Il13 mRNA in activated lymphocytes or protein in stimulated CD4+ T-cells. (J:89095)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
Insertion, Intergenic deletion
--
1
--
73

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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