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EN
To conditionally express the Epstein-Barr virus protein, LMP2A, from either the endogenous weak DQ52 promoter or an inserted strong Igh-V 186.2 promoter, sequence encoding LMP2A was inserted downstream of a loxP-flanked stop cassette. Floxed Igh-V 186.2 promoter sequence was included in the targeting vector between the DQ52 promoter and the floxed stop cassette (which contained frt-flanked neo followed by stop codons). Germline excision of the floxed Igh-V promoter and the stop cassette led to the production of Ightm5.1Cgn. (J:88472)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
