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A 55 bp segment of exon 2 was replaced with a cassette containing IRES, lacZ, and a floxed PGK-neomycin resistance gene. The DNA binding domain was disrupted and a frame shift was created in the process. A shorter mRNA transcript in which exon 1 is spliced directly to exon 3 was detected by Northern blot analysis. Immunoblot analysis indicated the absence of any protein product. Beta-galactosidase expression was not detected. (J:88534)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
