Log In|Sign Up
EN
Targeted disruption precluded the expression of 3 isoforms (Ae2a, Ae2b1, and Ae2b2) produced by the wild-type allele. A 1.5 kb genomic fragment encompassing exons 2, 1b2, and 1b1 was deleted in the germline using a cre-loxP system. The deleted exons each served as the initial coding exons for the Ae2a, Ae2b1, and Ae2b2 isoforms. The absence of transcript encoding these isoforms was verifed by RT-PCR analysis of homozygous mutant testes RNA. (J:88196)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
