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The floxed neo cassette was excised from Gli2tm5(GLI3)Alj, leaving the human GLI3 cDNA, flanked with an upstream FLAG epitope and a downstream mouse Gli2 3' UTR and three tandem repeats of a SV40 polyA signal, positioned within the first coding exon of the endogenous Gli2 locus. Western blot analysis of mutant mice indicated that the full length and the repressor form of the GLI3 protein were present. The level of GLI3 expression from this allele was reported to be greater than from Gli2tm5(GLI3)Alj. (J:87948)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
