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A lacZ gene was inserted in frame within exon 1 followed by a PGK-neomycin resistance gene. This replaced sequence from 356bp to 724bp downsteam of the initiator codon for the "B" isoform. As a result, the coding sequence for a 122aa fragment was removed including the initiation codon for the "A" isoform. Care was taken not to disrupt the estrogen response elements. (J:79968)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
