A genomic fragment encompassing exons 2 through 13 was replaced with a neo cassette inserted by homologous recombination. The deleted region encodes residues 11 through 1054, which encompass the all three dsRNA-binding domains, two putative Z-DNA-binding domains, and the majority of the catalytic domain. (J:87715)
Basic Information
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Insertion, Intragenic deletion
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count