Sequence encoding mutated nuclear localized lacZ with intragenic duplication corresponding to nucleotides 870-1987 after the ATG such that a shift in codon phase introduces a TGA STOP codon at nucleotide 1993 was inserted immediately after the start codon via homologous recombination. A floxed neo cassette included in the targeting vector was excised via cre-mediated recombination. The expression pattern of lacZ recapitulated that of the endogenous gene. (J:84604)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count