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The endogenous locus was disrupted a cassette encoding lacZ and GFP inserted downstream of the start codon via homologous recombination. A floxed neo cassette was also included in the targeting vector, but was excised via cre-mediated recombination in the germline. Neither normal transcript nor protein was detected by Northern and Western blot analyses of homozygous mutant mice. LacZ expression was realized via anti-beta-gal staining. (J:87892)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
