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Exon 8 was replaced with a gene trap cassette inserted by homologous recombination. The targeting vector included a splice acceptor site, stop codons in all reading frames, beta-geo initiated by its own start codon, and a polyadenylation signal. Mutant transcript consisting of exons 1 through 7 and the beta-geo sequence was detected by RT-PCR analysis. Western blot analysis identified a truncated protein in homozyous mutant mice, putatively containing the MEIS-homology domain. Beta-geo expression was realized by staining. (J:87890)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
