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A 2.5 kb genomic fragment, encompassing a portion of exon 1 and all of exons 2 through 6, was replaced with a neo cassette. The deletion was designed to eliminate both the secreted and transmembrane porteins produced by the endogenous locus. Tnfsf13 protein was undetected by FACS analysis of homozygous mutant splenocytes. Real-time RT-PCR indicated that the levels of Tnfsf12 and Senp3 transcript, produced by loci in close proximity to Tnfsf13, were not affected by the targeting event. (J:87680)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
