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A cassette containing IRES-lacZ and neo was inserted at codon 397, upstream of the carboxyl-terminal catalytic domain. Western blot analysis of lysates from cultured cells indicated an absence of protein of in homozygous mutant embyros. A 50% reduction of esterase activity in tissue homogenates obtained from heterozygous mutant mice indicated functional ablation. (J:87675)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
