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In order to ablate serine phosphorylation at codon 727, a serine to alanine substitution mutation was introduced into exon 23 at codon 727 via homologous recombination. A floxed neo cassette inserted downstream of the polyadenylation signal was excised via cre-mediated recombination. (J:87599)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
