Tg(mI56i-cre)6-1Clou

The intergenic distal-less homeobox 5/6 enhancer (mI56i) is a 440 bp fragment, endogenously located between Dlx5 and Dlx6. In this transgenic construct, mouse mI56i was included immediately downstream of cDNA encoding a nuclear localization signal and cre. Additionally, a minimal beta-globin promoter was included in the construct. Expression of cre recombinase was first realized at E9.5 and observed in the apical ectodermal ridge, brain, and neural crest-derived mesenchyme of pharyngeal. Additional indications of expression were identified along the smooth muscle of the outflow tract of the heart, however, this pattern was not observed in the 6-2 line. (J:87355)