Log In|Sign Up
EN
The loxP-flanked lacZ cassette was removed from Efnb2tm1.1Henk (frt-flanked neo excised from Efnb2tm1Henk) via cre-mediated recombination, generating a stop codon in exon 5. The nonsense mutation precludes the translation of the cytoplasmic tail (beyond codon 264). This allele is expected to encode a protein similar to Efnb2tm1.1Henk, but lacking beta-gal. Similarly, this mutation is expected to ablate reverse signaling while leaving forward signaling intact. (J:87497)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
