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Gene trap vector pGTO-fs inserted into the gene, included a beta galactosidase gene was inserted in intron 12. Resulting mice express a mutant protein composed of several hundred N-terminal amino acids fused to beta-galactosidase. This is a hypomorphic allele and wild-type mRNA is detectable in homozygotes by RT-PCR. (J:87046)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
