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The first 2 exons were replaced with a neomycin resistance gene. Absence of expression after this gene modification was confirmed by Northern blot analysis. A subsequent publication demonstrated that the targeting vector also replaced the first exon of the neighboring gene Mettl23, located on the opposite strand. RT-PCR confirmed absence of Mettl23 mRNA in homozygous embryos. (J:86771, J:137989)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
