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A floxed neomycin resistance gene was placed in intron 10 and an additional loxP site was placed in intron 12. Transient transfection of correctly targeted ES cells with a plasmid expressing Cre-recombinase eliminated the neomycin gene along with exons 11 and 12. Absence of protein product in resulting homozygous mice was demonstrated by Western blot analysis. (J:86770)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
