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Exons 2 and 3 which contain the two BH3 interaction domains were replaced with a floxed PGK-hygromycin resistance cassette. The resistance gene was excised in vivo by crossing to C57BL/6 Deleter mice. Gene disruption was confirmed by RT-PCR and by Northern blot analysis. (J:86466)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
