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The endogenous DQ52 and all four heavy chain J elements were replaced by the rearranged heavy chain VDJ region from VI10 (for a VSV-IND-neutralizing antibody) and a floxed neomycin resistance cassette. The neomycin cassette was removed in vivo by breeding to Cre deleter mice. Between 10 and 15% of B cells express this allele. (J:86411)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
