Nxf1^Mvb1

This allele codes for a pro at amino acid residue 48 and for a gly at amino acid residue 610. Carriers of this allele suppress disruptions at other gene loci caused specifically by intron insertions of IAP elements in the sense orientation only. This effect results from a quantitative shift in RNA isoforms from high molecular weight disrupted transcripts to correctly processed wild-type transcripts. Crosses with several alleles (Pitpnavb, Eya1bor, Aiy, Axin1Fu, Dab1scm, Hrhr, Myo5ad, and a) revealed that this allele can only suppress sense-orientation insertions (Pitpnavb and Eya1bor), including at least some class D elements, such as IAPS but not class C insertions, such as MLVs. (J:86371)