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0.3 kb of the first coding exon was replaced with a neomycin selection cassette inserted by homologous recombination. Transcript containing the neo cassette was detected by RT-PCR analysis of mutant mice. Mutant protein potentially encoded by the detected transcript lacks the catalytic unit and is putatively nonfunctional. Inositol 1,4,5-triphosphate 3-kinase activity was attenuated in a dose dependent manner in mutant mice. (J:86257)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
