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This transgene is composed of the rat Pepck promoter fused to a cDNA encoding amino acids 1-468 of human SREBP-2 followed by 2 stop codons. The 2.4 kb rat Pepck promoter is active in liver and adepose tissue. The cDNA portion encodes the 6HLH-zip domain and the NH2-terminal acidic transactivation domain. It lacks the membrane attachment domain and the COOH-terminal regulatory domain. Production of truncated product was determined by immunoblot analysis. (J:86518)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
