Sh2b2^tm1Yeb

Exons 1 through 6 were replaced with a neomycin selection cassette. Normal transcript was undetected by Northern blot analysis of homozygous mutant skeletal muscle and adipose tissue. While truncated transcript was identified in adipose tissue, protein was undetected by Western blot analysis using antibodies directed toward the N- and C-terminals. (J:86301)