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Site directed mutagenesis within exon 2 generated a missense mutation (AG>GC) at codon 18 resulting in the substitution of serine with alanine (p.S18A). Serine 18 corresponds with human serine 15 of TP53 and this mutation prevents phosphorylation of the residue in the encoded peptide. A single loxP site remained in intron 3 after the inserted loxP site flanked neomycin resistance gene cassette was excised via Cre-mediated recombination. (J:86520)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
