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Exons 1 and 2 were replaced with a cassette containing lacZ followed by floxed neo. The deleted sequence encodes 360 N-terminal residues which make up the octapeptide (Eh1 domain), alpha-helix 1, and approximately half of alpha-helix 2 homeodomain. Normal transcript was undetected by in situ hybridization of neural tube sections obtained from hemizygous fetuses. LacZ expression was detected. (J:86206)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
