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The human IL2RA gene was inserted into exon 2 of the endogenous locus. Thet targeting construct included a polyadenylation signal and neo gene immediately downstream of IL2RA. Treatment of mutant mice with a recombinant immunotoxin consisting of the variable regions of the anti-IL2RA monoclonal antibody fused to a bacterial exotoxin results in the specific ablation of cells expressing IL2RA via the Drd2 promoter. (J:85929)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
