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The loxP flanked region including exon 7 was excised from Ikbkbtm1Cgn via cre mediated recombination. The deleted region encoded amino acids 160 through 189, including serines 177 and 181, two residues of the activation loop that are essential for kinase activity. Excision of the floxed fragment results in splicing between exons 6 and 8, producing a protein that lacks kinase activity but that is incorporated into the Ikbk complex. (J:85810)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
