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A cassette containing lacZ and neo was inserted just downstream of the start codon in exon 1, such that the first 4 codons, which encode the signal peptide, were left intact. Protein was undetected in brain tissue of homozygous mutant mice by Western blot analysis using an antibody targeted against the endogenous extracellular domain. LacZ expression was verified by X-gal staining. (J:85827)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
