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Exon 1 of this gene as well as the entire VpreB1 gene were replaced with a neomycin resistance gene flanked by loxP sites. mRNA transcripts of this gene were not detected by Northern blot analysis but small amounts of a truncated product containing sliced exons 2 and 3 could be detected by PCR. No protein product was predicted from this mRNA. All mRNA product could be eliminated by cre mediated excision of the neomycin insert but this had no ultimate effect on the observed phenotypes. (J:76947)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
