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Glutamic acid codon 125 (GAA) in exon 3 was changed to glycine (GGA) (p.E125G) and glycine codon 126 (GGC) to serine (AGC) (p.G126S). The mutations are within the P-box of the first zinc finger of the encoded peptide and were shown, in vitro, to abolish DNA-binding while retaining the ability to interact with T3 and cofactors. A self-excising ACN cassette (loxP site + testis-specific ACE promoter driven cre gene + neomycin resistance gene cassette + loxP site) was inserted into intron 3. Western blot analysis showed endogenous levels of protein in homozygous mutant mice. (J:85158)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
