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A small part of the coding sequence for the regulatory domain and all of the sequence for the C-terminal catalytic domain were replaced by LacZ and a neomycin resistence gene. MEKK1 kinase activity was reduced in heterozygous ES cells and no activity was present in homozygous ES cells. (J:85346, J:85791)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
