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Elimination of the retina-specific L isoform was accomplished by replacing all of exon 1 and 18 bp of intron 1 with a cassette containing IRES-lacZ and MC1-neo. RT-PCR analysis of homozygous mutant mice showed that while transcripts encoding the M and S isoforms were present, transcript encoding the L isoform was absent. Reporter expression was observed but sporadic. (J:84905)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
