Exon 3, which encodes the majority of the CARD domain, was replaced with a neo cassette inserted by homologous recombination. Protein was undetected by Western blot analysis of whole cell lysates of bone marrow, thymus, lymph node, and spleen obtained from homozygous mutant mice. (J:85147)
Basic Information
Insertion, Intragenic deletion
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count