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A null allele was generated when 45.4 kb of the endogenous locus were deleted by the random insertion of a transgenic construct. The deleted region extended from within intron 1 to 31.2 kb downstream of the stop codon. The transgenic construct was comprised of an inducible murine Mx1 promoter adjoined to human T cell leukemia virus type 1 (HTLV1) Tax followed by intron 2 and non-coding exon 3 of the murine beta-globin locus. Endogenous transcript was reported to be undetected in homozygous mutant mice. (J:84754)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
